Carcinogenesis is a multistage process that involves numerous etiologies that work at different stages of tumor development. Carcinogenesis Food Toxicology Instructor: Gregory Möller, Ph.D. University of Idaho Food Toxicology 2 Learning Objectives • Define teratogenesis, mutagenesis, and carcinogenesis. PowerShow.com is a leading presentation/slideshow sharing website. Do you have PowerPoint slides to share? In which step of the cell ... Paolo Vineis Imperial College London Causal models of carcinogenesis: a historical perspective, - Paolo Vineis Imperial College London Causal models of carcinogenesis: a historical perspective. presentations for free. If you continue browsing the site, you agree to the use of cookies on this website. After you enable Flash, refresh this page and the presentation should play. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. They may act by altering uptake or metabolism of carcinogens by cells. DNA ... Feinberg et al. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. - CARCINOGENESIS: THE MOLECULAR BASIS OF CANCER In familial cases, children inherit one defective copy of the RB gene in the germ line; the other copy is normal. Initiation is the creation by genotoxic carcinogens of a cell with abnormal DNA. Stages of Carcinogenesis. ?? Or use it to find and download high-quality how-to PowerPoint ppt presentations with illustrated or animated slides that will teach you how to do something new, also for free. - Cell Replication is Essential for Multistage Carcinogenesis ... Modifying Factors in Chemical Carcinogenesis. According to etiologic factors ; Chemical ; Familial ; Physical ; Viral Alkylating agents, Antitumor antibiotics, Drugs have different mechanisms of action, Drugs may maximize the other drugs effect, Increase percent of cells killed at one time, Infusional therapy (runs over a number of hours), Combined modality therapy - chemo given with, 10 to 200 times higher than standard dose, Toxicities differ depending on length of time of, M2 is a way of determining BODY SURFACE AREA, Intrinsic resistance occurs prior to exposure to, Acquired malignant cells become resistant after, Complete response (CR) Absence of all tumor for, Stable disease (SD) lt 50 reduction or lt 25. ------------ Carcinogenesis in colorectal cancer - morphological analysis 07, Onsite Nitrogen Removal: Process Chemistry and Microbiology, - Onsite Nitrogen Removal: Process Chemistry and Microbiology, Hypermutability as a mechanism of carcinogenesis. Promotion. IV. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Cancer develops through four definable stages: initiation, promotion, progression and malignant conversion. Chemical Carcinogenesis: Initiation, Promotion and Progression. Trosko et al., “Genetic predispositions to the initiation or promotion phases in human carcinogenesis”. Redox signaling. Two leading hypotheses have emerged, luminal synthesis of carcinogen(s) and intramucosal carcinogenesis, outlined in Fig. Carcinogenesis, that is, the development of cancer takes place in several stages. Cell Proliferation. This initial damage rarely results in cancer because the cell has in place many mechanisms to repair damaged DNA. The process by which normal, healthy cells transform into cancer cells is termed carcinogenesis or oncogenesis. Briefly describe molecular basis of carcinogenesis. 1. 2. The “initiation” stage of carcinogenesis is an “irreversible” event which is in keeping with mutagenesis being (for all practical purposes) an irreversible event in DNA. Initiation is the creation by genotoxic carcinogens of a cell with abnormal DNA. Methylation reaction. Carcinogenesis, for example, is narrowly defined as the production of carcinoma but is more commonly used in the broadest possible sense to indicate generation of neoplasms which are new and typically abnormal growths, gener… The English version serves two purposes: as a learning aid for international students and to encourage German-speaking students to familiarize themselves with medical English; the lectures are delivered in German. As the process of successive mutation and prolifer… Palliation - Provide comfort, relief of symptoms, Prophylaxis - No disease but person at high risk, Phase 2 trials-determine efficacy in diseases, Phase 3 trials-compare to standard treatment, Phase 4 trials- determine other uses for drug, Work in a certain phase of cell growth cycle, Work best given continuously or frequently, Antimetabolites, plant alkaloids, miscellaneous, Cell kill proportional to amount of drug given. There is strong evidence that a critical step in carcinogenesis is a structural alteration occurring in the genetic machinery of a somatic cell. 6, which depicts the last stages of the carcinogenesis model (10). After initiation, promoters stimulate the replication of these neoplastic cells and facilitate the development of the tumour. - Nature Rev Genet (2002) 3; 415-428. Figure 1 Multistep chemical carcinogenesis can be conceptually divided into four stages: tumor initiation, tumor promotion, malignant conversion, and tumor progression. Nat Rev Genet (2006) 7; 21-33. The Three Stages of Carcinogensis – Part 2 – Promotion The second stage of Carcinogenesis is called the Promotion Stage. PPT – The Process of Carcinogenesis PowerPoint presentation | free to view - id: 7aa18-YzQyM, The Adobe Flash plugin is needed to view this content. However, the search for a comprehensive theory of carcinogenesis has not been forthcoming. Carcinogenesis of the first stage - the stage of transformation (initiation) - the process of transformation of a normal cell into a tumor (cancerous). Characteristics of Cancer. ... - NEOPLASIA Abdulmalik Alsheikh,M.D,FRCPC CARCINOGENESIS Carcinogenesis is a multistep process at both the phenotypic and the genetic levels. And, best of all, most of its cool features are free and easy to use. [See reference, J.E. ??????? Cell Proliferation (clonal expansion) Second Mutating Event. After cardiovascular diseases, it is the second cause of death This may occur randomly or when a carcinogen interacts with DNA causing damage. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. The first stage of carcinogenesis, initiation, results from an irreversible genetic alteration, most likely one or more simple mutations, transversions, transitions, and/or small deletions in DNA. Genes control cell division by cytokines. The process of carcinogenesis may be divided into at least three stages: initiation, promotion, and progression. Carcinogenesis ... Carcinogenesis is a multi-step process with multiple sequential 'hits' to the ... Chemical Carcinogenesis: Initiation, Promotion, Progression, - ENVR 430 Chemical Carcinogenesis: Initiation, Promotion, Progression Ivan Rusyn Laboratory of Environmental Genomics Department of Environmental Sciences & Engineering, - Title: Neoplasia Author: clinic-user Last modified by: pathology2.jed Created Date: 10/30/2008 12:39:27 PM Document presentation format: On-screen Show (4:3). National Cancer Institute National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Environmental Health Sciences Letter of Intent Receipt Dates: March 18, 1999; October 20, 1999 Application Receipt Dates: April 26, 1999; November 19, 1999 This … Review. If so, share your PPT presentation slides online with PowerShow.com. Progression "N" Mutating Event. They are all artistically enhanced with visually stunning color, shadow and lighting effects. The carcinogenic potential of ionizing radiation was recognized soon after Roentgen's discovery of X-rays in December, 1895. -In general, carcinogens are mutagens indicating that they have the potential to interact with DNA. Epigenetic progenitor model of tumorigenesis ... CARCINOGENESIS: THE MOLECULAR BASIS OF CANCER. Or use it to create really cool photo slideshows - with 2D and 3D transitions, animation, and your choice of music - that you can share with your Facebook friends or Google+ circles. Malignancy. Transformation is the result of interaction between a normal cell and a transforming agent (carcinogen). The PowerPoint PPT presentation: "The Process of Carcinogenesis" is the property of its rightful owner. By 1902, the first radiation-induced cancer was reported arising in an ulcerated area of the skin. Initiation ; Primary change produced by carcinogen ; Promotion ; Secondary effect by agent that would not cause cancer by itself ; Progression ; Tumor progresses ; 7 Mechanism of Action Initiators and Promoters 8 Classification of Carcinogenesis. - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Cell Proliferation. - Radiation-induced carcinogenesis Effect of Ionizing radiation Electromagnetic radiation (such as X- and gamma rays) are indirect ionizing radiation which deposits ... - Environmental Health Carcinogenesis Week 7 Genotoxicity: toxic effects on genetic material Cancer Developmental (gestational timing crucial) Somatic diseases The ... - Cell Proliferation and Carcinogenesis Kinetics of tumor cell population growth Growth fraction Cell loss Nutrient deprivation Immunological response against ... - ENVR 740 CHEMICAL CARCINOGENESIS Instructor: Avram Gold Office: McGavran-Greenberg 4114C Office phone: 6 7304 Lab: McGavran-Greenberg 3221E Lab phone: 6 7325. Many of them are also animated. Progression (irreversible) Different Steps of Carcinogenesis Initiation: Mutation in one or more cellular genes controlling key regulatory pathways of the cell (irreversible)—must be a heritable DNA alteration. carcinogenesis process has advanced, the identification of the carcinogen(s) remains elusive. To view this presentation, you'll need to allow Flash. - Niko Bla evi Mentor: A. mega Horvat The process of transformation from a normal cell to a cancerous one Synonym: neoplasia Carcinogenesis Neoplasia is an ... - An agent that induces cancer in a cell or group of cells. Initiation is the first step. Key words: cancer stages,carcinogenesis evaluation, chemical carcinogens, chemical carcinogenesis. Cancer cells are characterized by multiple structural, molecular and behavioural features. Introduction Five models of carcinogenesis. ??? Our ability to dissect oncogenic events is largely dependent on the availability of model systems that recapitulate human carcinogenesis at both the pathological and molecular levels. The development of a malignant tumour in otherwise healthy tissue is the result of a complex series of events beginning with a single cell that has acquired malignant properties through cellular DNA damage. Either Mutations or Epigenetic Events may Confer the Malignant Phenotypes of … ???????????? Looks like you’ve clipped this slide to already. In poison: Carcinogenesis …two main steps: initiation and promotion. Give ... Helicobacter pyloriinduced epithelial cell signalling in gastric carcinogenesis. • Summarize the mechanism of action for Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Pollinosis(allergic rhinitis), insect allergy & food allergy, Chronic nutritions treatments in childrens, No public clipboards found for this slide. Whether your application is business, how-to, education, medicine, school, church, sales, marketing, online training or just for fun, PowerShow.com is a great resource. Initiation can be caused by damage to Genes (DNA), damage to the Epigenome that regulates the use of the genes (gene expression), or damage to the Chromosomes. Classical Theory of Carcinogenesis, Initiators, and Tumor Promotors. Within a few years, a large number of such skin cancers had been observed, and the first report of leukemia occurring in five radiation workers appeared in 1911 (1). ???????? These stages may progress over many years. Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. Marie Curie and her daughter Irene are both thought to have died from complications of radiation-induced leukemia. Now customize the name of a clipboard to store your clips. In: … Initiating event involves cellular genome These lecture notes accompany my lectures on carcinogenesis in the study module "Tumors" at Innsbruck Medical University. • Describe the relevance of replication, transcription, and translation to teratogenesis, mutagenesis, and carcinogenesis. The activation of proto-oncogenes and the inactivation of tumor suppressor genes are mutational events that result from covalent damage to DNA caused by chemical exposures. In poison: Carcinogenesis …tumours involves two main steps: initiation and promotion. Transformation is the result of the interaction of a normal cell with a transforming agent (carcinogen). Carcinogenesis and Epigenetics By: Vicki Caligur, BioFiles 2008, 3.5, 18. 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